| APPLIED BIOANALYTICAL LABS providing tools for oxidative stress research |
 | |  | |  | |  | |  | |  |
| Contract Assay Service |
Our Services are focused on testing antioxidant and biomarkers related to oxidative damage in
samples ranging from plasma (serum), red blood cell, tissue biopsy, semen, wine, fruits, vegetables
and botanical extracts, for the purpose of wellness monitoring.
Our contract assay services are in four main categories: 1) Activities of antioxidant enzymes, 2) small molecule
biomarkers, 3) Total antioxidant capacities (excluding antioxidant enzymes, based on inhibition/retardation of
damage to a target molecule caused by free radicals), and 4) Direct observation of scavenging effect of
antioxidants on a specific free radical using electron spin resonance (EPR) spectroscopy.
samples ranging from plasma (serum), red blood cell, tissue biopsy, semen, wine, fruits, vegetables
and botanical extracts, for the purpose of wellness monitoring.
Our contract assay services are in four main categories: 1) Activities of antioxidant enzymes, 2) small molecule
biomarkers, 3) Total antioxidant capacities (excluding antioxidant enzymes, based on inhibition/retardation of
damage to a target molecule caused by free radicals), and 4) Direct observation of scavenging effect of
antioxidants on a specific free radical using electron spin resonance (EPR) spectroscopy.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
* Contact us if you need specific details and/or literature of our assay methods. A $39 extra sample processing
charge will be applied to each tissue sample submitted. Standard turnaround time is two weeks. Extra charges
for *rush* work will apply. Discounts are available for quantities over 5 samples, and we also offer special pricing
for major projects.
Please fill out our Sample Submission Form, you must include this form with your sample shipment.
Oxidative stress, antioxidant and wellness:
Reactive oxygen free radicals have been implicated in more than 100 human diseases and in aging process.
Tissue damage caused by free radicals is also well documented in trauma, toxin shocks, ischemia/reperfusion.
Following figure shows common endogenous and exogenous sources of reactive oxygen species (ROS).
charge will be applied to each tissue sample submitted. Standard turnaround time is two weeks. Extra charges
for *rush* work will apply. Discounts are available for quantities over 5 samples, and we also offer special pricing
for major projects.
Please fill out our Sample Submission Form, you must include this form with your sample shipment.
Oxidative stress, antioxidant and wellness:
Reactive oxygen free radicals have been implicated in more than 100 human diseases and in aging process.
Tissue damage caused by free radicals is also well documented in trauma, toxin shocks, ischemia/reperfusion.
Following figure shows common endogenous and exogenous sources of reactive oxygen species (ROS).
To prevent deleterious damage from ROS, human body has developed a powerful antioxidant defense system. It
includes enzymes such as superoxide dismutase, glutathione peroxidase and catalase to decompose these
harmful species, small free radical-scavenging molecules such as ascorbic acid, glutathione, uric acid, vitamin-E and
CoQ-10, and macromolecules to chelate metals and adsorb free radicals. Other small molecules from diet and
nutritional supplements also exhibit strong antioxidant properties.
includes enzymes such as superoxide dismutase, glutathione peroxidase and catalase to decompose these
harmful species, small free radical-scavenging molecules such as ascorbic acid, glutathione, uric acid, vitamin-E and
CoQ-10, and macromolecules to chelate metals and adsorb free radicals. Other small molecules from diet and
nutritional supplements also exhibit strong antioxidant properties.
Endogenous:
(OONO- -----> OH.) -----> ROO.
- Aerobic Respiration
- Leukocytes/Macrophages (Inflammation)
- Peroxisomes
- P450 – Liver
- Lipid Peroxidation Chain Reaction
(OONO- -----> OH.) -----> ROO.
Exogenous:
- Tobacco Smoking
- Ionizing Radiation
- UV Light Exposure
- Pollutants (including ozone)
- Organic Solvents
- Anesthetics
- Hyperoxic Environment
- Pesticides
- Some Medications